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Abstract #2608

Motion-Robust, Reduced-Distortion Diffusion MRI of the Liver with Optimized Motion Compensated Waveforms and Multi-shot EPI

Yuxin Zhang1,2, Matthias Muhler1, Ruiqi Geng1,2, Arnaud Guidon3, and Diego Hernando1,2
1Radiology, University of Wisconsin Madison, Madison, WI, United States, 2Medical Physics, University of Wisconsin Madison, Madison, WI, United States, 3Applications and Workflow, GE Healthcare, Boston, MA, United States

Conventional liver diffusion MRI acquisitions suffer from several challenges including low spatial resolution, B0-induced distortions, and elastic motion-induced signal voids. In this work, motion-robust and distortion-corrected liver diffusion-weighted imaging (DWI) was enabled by combining optimized motion compensated diffusion waveforms with multi-shot EPI acquisitions. Quantitative validation of distortions and ADC measurements was performed in healthy volunteer to assess the robustness and reproducibility of the combined techniques, as well as the synergistic effect of motion-robust gradient waveform and multi-shot EPI acquisitions. Preliminary patient example demonstrated the feasibility in patients with metastatic liver lesions.

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