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Abstract #2609

Quantitative magnetic resonance relaxometry for identifying lymphatic insufficiency in patients with secondary lymphedema

Paula Donahue1, Rachelle Crescenzi2, Chelsea Lee3, Niral J Patel3, Maria Garza2, Kalen Petersen2, and Manus Joseph Donahue2
1Physical Medicine and Rehabilitation, Vanderbilt Medical Center, Nashville, TN, United States, 2Radiology and Radiological Sciences, Vanderbilt Medical Center, Nashville, TN, United States, 3Pediatrics, Vanderbilt Medical Center, Nashville, TN, United States

MRI methods capable of evaluating tissue changes in response to lymphatic dysfunction have not been incorporated into lymphedema diagnosis and management owing to limited clinical evaluation of these technologies. We performed quantitative relaxometry in the skin and deep tissue of patients with lymphedema and matched controls, in sequence with standard biophysical bedside measures used for lymphedema assessment. In both deep tissue and skin, T2 was elevated in patients relative to control volunteers, consistent with edema, and relaxometry values were more discriminatory for category (i.e., control versus lymphedema) compared to common bedside tools of arm volume asymmetry and tissue dielectric constant.

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