Imaging differential diagnosis between Chondrosarcoma and enchondroma is still a challenge because of their similar characteristic. Radiomics1 is a concept that images contain information reﬂecting underlying pathophysiology and reveal relationship between lesions through quantitative image analyses. Out study aimed to develop radiomics models based on non-enhanced MRI to differentiate chondrosarcoma from enchondroma. Sixty-eight patients were retrospectively studied. The AUC of radiomics model based on TIWI , T2WI-FS were higher than that of conventional MRI (P＜0.01, 0.955, 0.901 and 0.569, respectively). Our preliminary study showed radiomics models can be used in differentiation of chondrosarcoma from enchondroma.