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Abstract #2683

Evaluation of Three Different Paradigms for Provoking Blood Oxygenation Level-Dependent MRI Signal Changes in Skeletal Muscles

Shiteng Suo1, Hui Tang1, Qing Lu1, and Jianrong Xu1
1Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

Stress BOLD MRI allows for quantitative evaluation of blood flow reserve in skeletal muscles. In this study, we conducted a head-to-head comparison between three commonly used stressors including gas inhalation, cuff compression induced ischemia and postocclusive reactive hyperemia, and exercise. Results showed that different paradigms could produce different BOLD signal variation profiles. Both correlation and discrepancy can be noted regarding to the relationship between BOLD MRI and TcPO2 measurements. Ischemia and reactive hyperemia paradigm had better interobserver/interscan reproducibility, exercise had larger signal alterations, and both can reveal the age-dependent differences in BOLD signal and may be preferred in further applications.

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