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Abstract #2684

Characterization of the Microenvironment of the Intervertebral Disc in Patients with Chronic Low Back Pain by Z-spectral imaging

Li Li1, Jicheng Fang1, Alessandro Scotti2, Mehran Shaghaghi2, Wenzhen Zhu1, and Kejia Cai2
1Radiology, Tongji Hospital, Tongji Medical College,HUST, Wuhan, China, Wuhan, China, 2Radiology, 1.Radiology Dept., 2. Bioengineering Dept., College of Medicine, University of Illinois at Chicago, Chicago, IL, United States, Chicago, IL, United States

To assess the microenvironment changes of intervertebral disc degeneration, ZSI data were collected from the lumbar spine of 26 patients with CLBP and 21 AC and produced maps of NOE, Water, GAG, APT, MTC. By comparing such parameters between the two groups, it was revealed that the microenvironment of the discs in AC group was different from the discs in the CLBP group. And, the microenvironment of the discs in the sore and non-sore subgroup was also different. ZSI is a noninvasive technique that can be used to test the changes of the microenvironment of the intervertebral discs.

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