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Abstract #2697

Comparison of simulated and experimental stimulated echo diffusion at varying diffusion times in skeletal muscle

Erin K Englund1, David B Berry2, Vitaly Galinsky3, Lawrence R Frank3, and Samuel R Ward1,3,4
1Orthopaedic Surgery, University of California San Diego, La Jolla, CA, United States, 2Nanoengineering, University of California San Diego, La Jolla, CA, United States, 3Radiology, University of California San Diego, La Jolla, CA, United States, 4Bioengineering, University of California San Diego, La Jolla, CA, United States

Diffusion tensor imaging provides insight into the underlying tissue microstructure. Here, we compare simulated DTI data to experimentally acquired data in skeletal muscle using stimulated echo DTI at multiple diffusion encoding times. After adjusting for the difference in simulated versus measured apparent diffusion coefficient, there was relative agreement of mean diffusivity and radial diffusivity between the measured and simulated data. Fractional anisotropy was overestimated experimentally, likely due to limited image SNR.

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