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Abstract #2698

Evaluating Longitudinal Muscle Degeneration in ALS Patients using MR Cytography

Sudarshan Ragunathan1, Laura C Bell1, Ashley M Stokes1, Natenael Semmineh1, Jessie Duncan2, Nicole Turcotte2, Shafeeq Ladha2, and Chad C Quarles1
1Neuroimaging Research, Barrow Neurological Institute, Phoenix, AZ, United States, 2Gregory W. Fulton ALS and Neuromuscular Center, Barrow Neurological Institute, Phoenix, AZ, United States

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by loss of upper and lower motor neurons (UMN and LMN), resulting in muscle atrophy and eventual death. Clinical indicators such as ALSFRS-R scores can be confounded by inter-rater variability and low sensitivity. MR Cytography based TRATE has been shown to identify changes to myofiber microstructure. This work aims to demonstrate that TRATE is a more sensitive and consistent metric to evaluate longitudinal muscle degeneration in ALS patients than existing clinical indicators such as ALSFRS-R scores.

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