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Abstract #2701

Diffusion tensor imaging of calf muscle damage in peripheral arterial disease

Jianli Wang1, Jonathan Stavres2, Christopher T Sica1, Cheryl Blaha2, Michael Herr2, Samuel Pai2, Aimee Cauffman2, Jeffrey Vesek3, Qing X Yang1,4, and Lawrence I Sinoway2
1Radiology, Penn State College of Medicine, Hershey, PA, United States, 2Heart & Vascular Institute, Penn State College of Medicine, Hershey, PA, United States, 3Molecular Biology, Penn State College of Medicine, Hershey, PA, United States, 4Neurosurgery, Penn State College of Medicine, Hershey, PA, United States

Peripheral arterial disease (PAD) is a systemic atherosclerotic vascular disease characterized by impaired skeletal muscle perfusion and mitochondrial respiration. Over time, persistent exposure to muscle ischemia eventually leads to muscle atrophy, myopathy, and mitochondrial dysfunction in PAD patients. In this study we investigated the utilization of diffusion tensor imaging to characterize the pathophysiological changes of calf muscles before and after graded plantar flexion exercise. At rest, the clinically worse leg of the PAD subjects had higher diffusivity in the calf muscles. Significant greater increases of diffusivity in the post-exercise muscle of PADs than the HCs suggest acute exercise-related muscle damage.

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