Abstract #2702

Comparison of measurements of intramuscular fat from T1-weighted and mDixon MRI scans in people with and without spinal cord injury

Bart Bolsterlee^1,2, Elizabeth A Bye^3,4, Junya Eguchi^1,5, Joanne Glinsky³, Jeanette Thom⁵, and Robert D Herbert^1,5

¹Neuroscience Research Australia, Randwick, Australia, ²Graduate School of Biomedical Engineering, University of New South Wales, Randwick, Australia, ³John Walsh Centre for Rehabilitation Research, Sydney University, Sydney, Australia, ⁴Spinal Injury Unit, Prince of Wales Hospital, Randwick, Australia, ⁵School of Medical Sciences, University of New South Wales, Randwick, Australia

Accurate quantification of fat content of human muscles could help assess disease status and test effectiveness of interventions in people with neurological conditions, whose muscles are frequently infiltrated with fat. We compared two commonly used MRI methods based on T1-weighted and mDixon scans to quantify intramuscular fat in 112 muscles from people with and without spinal cord injury. Fat fraction measurements agreed well in muscles with high proportions of fat, but the T1-weighted method could not be used in muscles with small proportions of fat. We recommend against the use of T1-weighted methods to quantify intramuscular fat.

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