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Abstract #2707

Variability of Diffusion Tensor MRI, 2-Point Dixon fat fraction and T2 relaxation in ROIs of thigh muscle in rheumatoid arthritis patients 

Dominic Bertham1,2, Matthew Farrow3, Ai Lyn Tan3, Steven Tanner1, Paul Emery3, and John Biglands1
1Leeds Biomedical Research Centre, Leeds, United Kingdom, 2Department of Health Sciences, University of York, York, United Kingdom, 3Leeds institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom

Muscular weakness is associated with fatty infiltration and changes to muscle fibre structure. Quantitative magnetic resonance imaging (MRI) may be able to detect subtle muscle changes in rheumatoid arthritis (RA) patients. Before this method is used, variability of MRI measurements involving regions of interest (ROI) must first be measured. Fat fraction, T2 measurement and diffusion tensor imaging was performed on 19 participants with RA. Intra-rater and inter-rater variability of MRI measurements for thigh muscle ROIs were assessed. Inter-rater and intra-rater variability scores were high, suggesting that these measurements are sufficiently precise to allow the study of subtle changes to muscle.

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