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Abstract #2710

The effect of ageing on skeletal muscle as assessed by quantitative MR imaging: an association with frailty and muscle strength

Matt Farrow1, John Biglands1, Steven F Tanner1, Elizabeth Hensor1, Philip O'Connor1, Paul Emery1, and Ai Lyn Tan1
1University of Leeds, Leeds, United Kingdom

The proportion of older people in the population is increasing. It is known that muscle health deteriorates with age, resulting in a loss of muscle mass and strength, known as sarcopenia. This study demonstrates that ageing is associated with a significant increase in fat fraction and T2 and a significant decrease in muscle volume, grip strength and muscle power. Quantitative MRI parameters correlated with frailty index, grip strength and muscle power. Therefore, quantitative MRI measurements have the potential to be useful markers of age and muscle health and can be used in the management and treatment of sarcopenia and frailty.

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