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Abstract #2709

Assessment of peripheral muscle deconditioning usingĀ 31P-MRS during high intensity ischaemic plantar flexion exercise

Jordan McGing1, Rosemary Nicholas1, Sebastien Serres2, Paul Greenhaff2, Gordon Moran3, and Susan Francis1
1Sir Peter Mansfield Imaging Centre, Nottingham, United Kingdom, 2University of Nottingham, Nottingham, United Kingdom, 3Nottingham Digestive Diseases Centre, Nottingham, United Kingdom

Non-invasive assessment of muscle quality is of relevance in chronic disease, where muscle deconditioning is prevalent. To quantify PCr kinetics, localised and non-localised 31P acquisitions were performed during ischemic plantar flexion exercise and recovery. Application of non-localised 31P acquisition resolved motion induced phasing issues and low temporal resolution apparent in 31P ISIS data acquisitions. This allowed quantitation of PCr kinetics in response to high intensity ischemic exercise, successfully providing a surrogate marker of muscle quality in fatigued CD patients. Application of this within-bore exercise protocol to fatigued CD patients and healthy control volunteers will provide insight into pathological fatigue mechanisms.

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