Though oldest noninvasive imaging biomarker for creatine kinase (CK) reaction in exercised muscle, phosphorous magnetic resonance spectroscopy (31PMRS) suffers from the poor resolution. The 2D creatine Chemical Exchange Saturation Transfer allows for the assessment of creatine recovery with excellent in plane spatial resolution, it was not possible to construct voxel wise parametric maps for recovery time constant due to low signal to noise ratio (SNR). Recently developed 3D implementation of CrCEST allowed for higher SNR and increased volumetric coverage and we exploit these two advantages in our novel non-local spatially regularized approach to reconstruct parametric map for recovery time constant.
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