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Abstract #2718

Metabolic Imaging of Skeletal Muscle in Aging Rats: Potential for improving muscle metabolism with Rapamycin

Rengaraj Anantharaj1, Jadegoud Yaligar1, Giang Thi Thu Le1, Venkatesh Gopalan1, Sanjay Kumar Verma1, Kavita Kaur1, Kasthuri Thirumurugan2, Johan G Eriksson2,3, Brian Kennedy4, and S Sendhil Velan1,2
1Laboratory of Molecular Imaging, Singapore Bioimaging Consortium, A*STAR, Singapore, Singapore, 2Singapore Institute for Clinical Sciences, A*STAR, Singapore, Singapore, 3Department of Obstetrics & Gynecology, National University of Singapore, Singapore, Singapore, 4Center for Healthy Aging, National University of Singapore, Singapore, Singapore

Aging associated loss of muscle mass leads to metabolic diseases and compromised quality of life. Increase in intramyocellular lipid (IMCL) and reduced skeletal muscle mass are associated with insulin resistance and diabetes. Rapamycin increases muscle mass by inhibiting the mTOR signalling pathway. In this study, we investigated IMCL metabolism and muscle mass in response to rapamycin intervention in an aging rodent model. We observed significant reduction in IMCL along with increase in muscle mass indicating improved muscle metabolism with rapamycin intervention. Muscle differentiation gene, MyoD was upregulated and myostatin which is negative regulator of muscle growth factor was down regulated.

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