Abstract #2719

Measuring Spontaneous Muscular Activities in Neuromuscular Disease: Preliminary Results

Martin Schwartz^1,2, Petros Martirosian¹, Günter Steidle¹, Thomas Küstner^1,2,3, Bin Yang², Alto Stemmer⁴, Thorsten Feiweier⁴, Ludger Schöls^5,6, Matthis Synofzik^5,6, and Fritz Schick¹

¹Section on Experimental Radiology, University Hospital of Tuebingen, Tuebingen, Germany, ²Institute of Signal Processing and System Theory, University of Stuttgart, Stuttgart, Germany, ³School of Biomedical Engineering & Imaging Sciences, King's College London, St. Thomas' Hospital, London, United Kingdom, ⁴Siemens Healthcare GmbH, Erlangen, Germany, ⁵Department Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, Tübingen & Center for Neurology, Tuebingen, Germany, ⁶German Center for Neurodegenerative Diseases (DZNE), Tuebingen, Germany

Quantification of spontaneous mechanical activities in musculature like fibrillations or fasciculations is of high interest for the assessment of neuro-muscular function in normal and impaired subjects. The diagnostic assessment of neuromuscular disease focuses at specific muscular regions, and the measurement protocol was optimized in order to robustly quantify spontaneous activities in these areas. This work shows preliminary results regarding activity patterns of healthy and diseased subjects.

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