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Abstract #2719

Measuring Spontaneous Muscular Activities in Neuromuscular Disease: Preliminary Results

Martin Schwartz1,2, Petros Martirosian1, Günter Steidle1, Thomas Küstner1,2,3, Bin Yang2, Alto Stemmer4, Thorsten Feiweier4, Ludger Schöls5,6, Matthis Synofzik5,6, and Fritz Schick1
1Section on Experimental Radiology, University Hospital of Tuebingen, Tuebingen, Germany, 2Institute of Signal Processing and System Theory, University of Stuttgart, Stuttgart, Germany, 3School of Biomedical Engineering & Imaging Sciences, King's College London, St. Thomas' Hospital, London, United Kingdom, 4Siemens Healthcare GmbH, Erlangen, Germany, 5Department Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, Tübingen & Center for Neurology, Tuebingen, Germany, 6German Center for Neurodegenerative Diseases (DZNE), Tuebingen, Germany

Quantification of spontaneous mechanical activities in musculature like fibrillations or fasciculations is of high interest for the assessment of neuro-muscular function in normal and impaired subjects. The diagnostic assessment of neuromuscular disease focuses at specific muscular regions, and the measurement protocol was optimized in order to robustly quantify spontaneous activities in these areas. This work shows preliminary results regarding activity patterns of healthy and diseased subjects.

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