Abstract #2724

CrCEST effects in Knee Osteoarthritis Patients following Plantar Flexion Exercise of lower leg skeletal muscle at 7.0T

Deepa Thakuri¹, Dushyant Kumar¹, Abigail Cember¹, Ravi Prakash Reddy Nanga¹, Lizbeth Novelo², Hari Hariharan¹, Joshua Baker², and Ravinder Reddy¹

¹Radiology, University of Pennsylvania, Philadelphia, PA, United States, ²Rheumatology & Epidemiology, University of Pennsylvania, Philadelphia, PA, United States

Osteoarthritis (OA) is the leading cause of disability in adult and aging populations. Knee OA increases difficulty in the functional use of various upper and lower leg muscles. In the recent years, CrCEST technique has emerged as a potential imaging biomarker to study muscle metabolism and its application was shown in different systemic diseases like mitochondrial disorders. Here, we are particularly interested in exploring and investigating the correlation of knee OA with post exercise CrCEST increase.

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