Increased intramyocellular and extramyocellular lipids (IMCL and EMCL), abdominal lipids and decreased lipid unsaturation ratios, are of prime interest in determining relationships of these changes to insulin sensitivity and progression to type 2 diabetes (T2DM). We acquired 6-point Dixon based MRI of abdomen and accelerated MR Spectroscopic Imaging in calf muscle. In the T2DM group, BMI correlated positively with visceral fat, total fat and hepatic fat fractions. In contrast, BMI correlated negatively with pancreatic fat fractions (body/tail) in age-matched healthy volunteers. Mostly association between IMCL unsaturation index and abdominal fat content was observed. Also, we found an excellent correlation between abdominal lipid accretion and calf muscle lipid infiltration in T2DM and healthy controls predominantly inside muscle fibers (IMCL).
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