Abstract #2738

Detecting Early Changes in ACL-Reconstructed Knees: Cluster Analysis of T2 Relaxation Times from 3 Months to 18 Months Post-Surgery

Marianne S Black^1,2, Katherine A Young¹, Akshay S Chaudhari¹, Feliks Kogan¹, Bragi Sveinsson³, Emily J McWalter⁴, Garry E Gold^1,5, Marc E Levenston^1,2, and Brian A Hargreaves^1,5,6

¹Radiology, Stanford University, Stanford, CA, United States, ²Mechanical Engineering, Stanford University, Stanford, CA, United States, ³Massachusetts General Hospital, Boston, MA, United States, ⁴Mechanical Engineering, University of Saskatchewan, Saskatoon, SK, Canada, ⁵Bioengineering, Stanford University, Stanford, CA, United States, ⁶Electrical Engineering, Stanford University, Stanford, CA, United States

There is a need to detect and quantify early osteoarthritic changes for the development of treatments for osteoarthritis progression. ACL-injured subjects are at an increased risk of developing osteoarthritis, and T₂ is sensitive to the structure and composition of cartilage, including osteoarthritic change. This study used a quantitative DESS acquisition to obtain T₂ maps in 10 subjects 3-weeks, 3-months, 9-months, and 18-months after ACL reconstruction surgery and 10 controls at matched times. Our results show that T₂ cluster analysis was able to detect changes to the ACL-reconstructed cartilage as early as 3-months post-surgery and these differences persisted at 18-months.

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