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Abstract #2738

Detecting Early Changes in ACL-Reconstructed Knees: Cluster Analysis of T2 Relaxation Times from 3 Months to 18 Months Post-Surgery

Marianne S Black1,2, Katherine A Young1, Akshay S Chaudhari1, Feliks Kogan1, Bragi Sveinsson3, Emily J McWalter4, Garry E Gold1,5, Marc E Levenston1,2, and Brian A Hargreaves1,5,6
1Radiology, Stanford University, Stanford, CA, United States, 2Mechanical Engineering, Stanford University, Stanford, CA, United States, 3Massachusetts General Hospital, Boston, MA, United States, 4Mechanical Engineering, University of Saskatchewan, Saskatoon, SK, Canada, 5Bioengineering, Stanford University, Stanford, CA, United States, 6Electrical Engineering, Stanford University, Stanford, CA, United States

There is a need to detect and quantify early osteoarthritic changes for the development of treatments for osteoarthritis progression. ACL-injured subjects are at an increased risk of developing osteoarthritis, and T2 is sensitive to the structure and composition of cartilage, including osteoarthritic change. This study used a quantitative DESS acquisition to obtain T2 maps in 10 subjects 3-weeks, 3-months, 9-months, and 18-months after ACL reconstruction surgery and 10 controls at matched times. Our results show that T2 cluster analysis was able to detect changes to the ACL-reconstructed cartilage as early as 3-months post-surgery and these differences persisted at 18-months.

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