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Abstract #2737

qDESS ADC as a Biomarker for Early Degeneration in Femoral Cartilage of Post-Reconstruction ACL Tear Patients and Correlation with DWI-EPI ADC

Mary Elizabeth Hall1,2, Valentina Mazzoli2, Marianne Black1,2, Halston Sandford2, Katherine Young2, Daehyun Yoon2, Bragi Sveinsson3, Akshay Chaudhari2, Emily McWalter4, Feliks Kogan2, Marc Levenston1,2,5, Brian Hargreaves2,5,6, and Garry Gold2
1Mechanical Engineering, Stanford University, Stanford, CA, United States, 2Radiology, Stanford University, Stanford, CA, United States, 3Massachusetts General Hospital, Boston, MA, United States, 4Mechanical Engineering, University of Saskatchewan, Saskatoon, SK, Canada, 5Bioengineering, Stanford University, Stanford, CA, United States, 6Electrical Engineering, Stanford University, Stanford, CA, United States

This study evaluates apparent diffusion coefficient (ADC) as measured by a quantitative double echo steady state (qDESS) sequence as a biomarker for early osteoarthritis detection in articular cartilage in the femur and its correlation with ADC from a diffusion weighted echo planar (DWI-EPI) scan. 9 injured knees and contralateral knees of patients undergoing reconstruction surgery following anterior cruciate ligament tears were scanned with qDESS and DWI-EPI sequences up to 18 months post surgery. There were no consistent patterns of qDESS ADC change on a global or regional basis in the femoral cartilage. qDESS ADC did not correlate with DWI-EPI ADC.

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