Abstract #2737

qDESS ADC as a Biomarker for Early Degeneration in Femoral Cartilage of Post-Reconstruction ACL Tear Patients and Correlation with DWI-EPI ADC

Mary Elizabeth Hall^1,2, Valentina Mazzoli², Marianne Black^1,2, Halston Sandford², Katherine Young², Daehyun Yoon², Bragi Sveinsson³, Akshay Chaudhari², Emily McWalter⁴, Feliks Kogan², Marc Levenston^1,2,5, Brian Hargreaves^2,5,6, and Garry Gold²

¹Mechanical Engineering, Stanford University, Stanford, CA, United States, ²Radiology, Stanford University, Stanford, CA, United States, ³Massachusetts General Hospital, Boston, MA, United States, ⁴Mechanical Engineering, University of Saskatchewan, Saskatoon, SK, Canada, ⁵Bioengineering, Stanford University, Stanford, CA, United States, ⁶Electrical Engineering, Stanford University, Stanford, CA, United States

This study evaluates apparent diffusion coefficient (ADC) as measured by a quantitative double echo steady state (qDESS) sequence as a biomarker for early osteoarthritis detection in articular cartilage in the femur and its correlation with ADC from a diffusion weighted echo planar (DWI-EPI) scan. 9 injured knees and contralateral knees of patients undergoing reconstruction surgery following anterior cruciate ligament tears were scanned with qDESS and DWI-EPI sequences up to 18 months post surgery. There were no consistent patterns of qDESS ADC change on a global or regional basis in the femoral cartilage. qDESS ADC did not correlate with DWI-EPI ADC.

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