A self-compensated spin-locking (SL) scheme for quantitative R1ρ dispersion in cartilage has been developed. The performance of this new method was evaluated by Bloch simulations and R1ρ dispersion (with 6 SL RF strengths ranging from 50 to 1000 Hz) studies on agarose (1-4%, w/v) phantom and on one healthy human knee in vivo at 3T, with respect to three reported SL approaches. The simulated and experimental results indicate that the proposed SL method was less susceptible to B0 and B1 field artifacts for a wide range of SL strengths, and thus more suitable for quantitative R1ρ dispersion in ordered tissue.
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