Abstract #2735

To Evaluate the Effect of Normalization on Femur Cartilage T2 Values in Diagnosis of Osteoarthritis

Rafeek Thaha¹, Sandeep Panwar Jogi^1,2, Sriram Rajan³, Amit Mehndiratta^1,4, Anup Singh^1,4, and Dharmesh Singh¹

¹Centre for Biomedical Engineering, Indian Institute of Technology, New Delhi, India, ²Biomedical Engineering, ASET, Amity University Haryana, Gurgaon, India, ³Mahajan Imaging Centre, New Delhi, India, ⁴Department of Biomedical Engineering, All India Institute of Medical Sciences, New Delhi, India

Quantitative MR parameters(such as T2-relaxation time) are sensitive to biochemical changes in the cartilage. The objective of the study was to evaluate the performance of different statistics parameters from T2 values of femur cartilage and normalized T2 map (Z-score T2 map) values for differentiating healthy vs OA patients as well as Early-OA (Grade-I and Grade-II), vs Risk-OA (Grade-III) patients. Multiple Statistic parameter from T2 map provided high accuracy in differentiation between healthy vs OA cartilage, while one of the static parameter of Z-score T2 map provided high accuracy in differentiation between early-OA vs Risk-OA.

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