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Abstract #2754

Cluster analysis of T2 changes is related to acute exercise in individuals with knee osteoarthritis

Lauren Watkins1, Valentina Mazzoli2, Marianne Black3, Scott Uhlrich3, Brian Hargreaves1,2,4, Garry Gold2, and Feliks Kogan2
1Bioengineering, Stanford University, Stanford, CA, United States, 2Radiology, Stanford University, Stanford, CA, United States, 3Mechanical Engineering, Stanford University, Stanford, CA, United States, 4Electrical Engineering, Stanford University, Stanford, CA, United States

Degradation of articular cartilage related to osteoarthritis is associated with changes in cartilage T2 relaxation times that may not be uniform across the cartilage surface. Analysis of changes in T2 times longitudinally or in response to mechanical loading can assist in detection of regions of cartilage damage. Here we examine the ability of cluster analysis to reflect transient changes in cartilage T2 times in response to acute loading. Osteoarthritic subjects who performed a squat exercise had a greater percent of the cartilage area with negative changes in T2 times compared to healthy and osteoarthritic subjects who did not exercise.

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