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Abstract #2753

Investigation into the effect of spin-lock frequency on the angular dependence of T1rho in in-vivo measurements of femoral knee cartilage at 3T

Laurel Hales1 and Feliks Kogan2
1Electrical Engineering, Stanford University, Stanford, CA, United States, 2Radiology, Stanford University, Stanford, CA, United States

Given the use of T1rho as a measure of cartilage health and an early indicator for osteoarthritis, it is important to understand the T1rho relaxation mechanism including its somewhat unexplained angular dependence. In the hope of finding a range of spin-lock frequencies (FSLs) with a decreased angular dependence, we generated T1rho maps of in-vivo femoral knee cartilage at various FSLs from 100Hz to 1kHz. We found a visible angular dependence in T1rho measurements for all FSLs including 1kHz. If there exists a range of FSL with little or no angular dependence it is higher than 1kHz.

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