Abstract #2759

Variable flip angle T1 Relaxometry of cortical bone free water; correlation with the mechanical compression test

Mahsa Talebi^1,2, Shahrokh Abbasi-Rad³, Malakeh Malekzadeh^1,4, Mohamad Shahgholi⁵, Kimia Foudeh⁵, and Hamidreza Saligheh Rad^1,2

¹Quantitative MR Imaging and Spectroscopy Group, Research Center for Cellular and Molecular Imaging, Tehran University of Medical Sciences, Tehran, Iran, Tehran, Iran (Islamic Republic of), ²Medical Physics and Biomedical Engineering Department, Tehran University of Medical Sciences, Tehran, Iran, Tehran, Iran (Islamic Republic of), ³Quantitative MR Imaging and Spectroscopy Group, Research Center for Cellular and Molecular Imaging, Tehran University of Medical Sciences, Tehran, Iran, Brisbane, Australia, ⁴3Medical Physics Department, School of Medicine, Iran University of Medical Sciences, Tehran, Iran, Tehran, Iran (Islamic Republic of), ⁵Department of Mechanical Engineering, Najafabad Branch, Islamic Azad University, Najafabad, Iran, Najaf Abad, Iran (Islamic Republic of)

Cortical bone porosity contributes to bone quality but is under the limit of the current clinical imaging modalities’ resolution. T1 value of water molecules residing in cortical bone pores is linked with their mobility. Since the changes in surface-to-volume ratio of the pores affect cortical bone mechanical properties, we assumed that free water T1 (T1,free) would model the mechanical properties of cortical bone. Variable flip angle, variable TR, and inversion recovery methods were used to quantify T1,free and their correlation with bone toughness was assessed. The results showed VFA T1,free could predict the cortical bone toughness (r = -0.63, p<0.01).

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