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Abstract #2758

Evaluation of bone marrow proton density fat fraction in β-thalassaemia patients and healthy subjects using 1H-MR spectroscopy. 

Umi Nabilah Ismail1, Che Ahmad Azlan1, Shasha Khairullah2, Kuan Jin Lee3, Chai Hong Yeong4, Nur Farhayu Omar5, Mohammad Nazri M Shah1, Raja Rizal Azman Raja Aman1, Nicholas Jackson6, and Kwan Hoong Ng1
1Biomedical Imaging Department, University of Malaya, Kuala Lumpur, Malaysia, 2Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia, 3Singapore Bioimaging Consortium, A*STAR Research, Singapore, Singapore, 4School of Medicine, Faculty of Health and Medical Sciences, Taylor's University Lakeside Campus, Subang Jaya, Malaysia, 5Department of Imaging, Universiti Putra Malaysia, Serdang, Malaysia, 6Department of Pathology, University of Malaya, Kuala Lumpur, Malaysia

Fat in bone marrow is stated to be regulated by the body haematopoietic needs. We explored this by measuring bone marrow fat fraction(FF) of healthy subjects and β-thalassaemia patients who required treatment to suppress their body haematopoietic needs. The results obtained from 1H-MR Spectroscopy suggested that information about marrow adipocytes may be useful in evaluating patients' treatment response.

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