Abstract #2758

Evaluation of bone marrow proton density fat fraction in β-thalassaemia patients and healthy subjects using 1H-MR spectroscopy.

Umi Nabilah Ismail¹, Che Ahmad Azlan¹, Shasha Khairullah², Kuan Jin Lee³, Chai Hong Yeong⁴, Nur Farhayu Omar⁵, Mohammad Nazri M Shah¹, Raja Rizal Azman Raja Aman¹, Nicholas Jackson⁶, and Kwan Hoong Ng¹

¹Biomedical Imaging Department, University of Malaya, Kuala Lumpur, Malaysia, ²Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia, ³Singapore Bioimaging Consortium, A*STAR Research, Singapore, Singapore, ⁴School of Medicine, Faculty of Health and Medical Sciences, Taylor's University Lakeside Campus, Subang Jaya, Malaysia, ⁵Department of Imaging, Universiti Putra Malaysia, Serdang, Malaysia, ⁶Department of Pathology, University of Malaya, Kuala Lumpur, Malaysia

Fat in bone marrow is stated to be regulated by the body haematopoietic needs. We explored this by measuring bone marrow fat fraction(FF) of healthy subjects and β-thalassaemia patients who required treatment to suppress their body haematopoietic needs. The results obtained from 1H-MR Spectroscopy suggested that information about marrow adipocytes may be useful in evaluating patients' treatment response.

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