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Abstract #2774

Predicting cortical bone microstructural properties by water proton density obtained from ultrashort echo time (UTE) MRI

Saeed Jerban1, Yajun Ma1, Hyungseok Jang1, behnam namiranian1, Nicole Le2, Hoda Shirazian1, Mark Murphy3, Jiang Du1, and Eric Y Chang2
1Radiology, University of California, San Diego, San Diego, CA, United States, 2Radiology Service, VA San Diego Healthcare System, San Diego, CA, United States, 3Orthopaedic Service, VA San Diego Healthcare System, San Diego, CA, United States

Cortical bone porous microstructure can be potentially predicted by the total water density in bone. Comparing bone signal from a relatively fast ultrashort echo time MRI (UTE-MRI) scan against the signal of a known external reference (rubber eraser) enabled us to measure total water proton density (TWPD) in 135 cortical bone specimens from 37 donors. We observed significant correlations between bone TWPD and micro computed tomography (╬╝CT) measures (porosity, pore size, and bone mineral density, (BMD)). This relatively fast MRI technique may aid diagnosing and monitoring bone diseases.

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