Abstract #2774

Predicting cortical bone microstructural properties by water proton density obtained from ultrashort echo time (UTE) MRI

Saeed Jerban¹, Yajun Ma¹, Hyungseok Jang¹, behnam namiranian¹, Nicole Le², Hoda Shirazian¹, Mark Murphy³, Jiang Du¹, and Eric Y Chang²

¹Radiology, University of California, San Diego, San Diego, CA, United States, ²Radiology Service, VA San Diego Healthcare System, San Diego, CA, United States, ³Orthopaedic Service, VA San Diego Healthcare System, San Diego, CA, United States

Cortical bone porous microstructure can be potentially predicted by the total water density in bone. Comparing bone signal from a relatively fast ultrashort echo time MRI (UTE-MRI) scan against the signal of a known external reference (rubber eraser) enabled us to measure total water proton density (TWPD) in 135 cortical bone specimens from 37 donors. We observed significant correlations between bone TWPD and micro computed tomography (μCT) measures (porosity, pore size, and bone mineral density, (BMD)). This relatively fast MRI technique may aid diagnosing and monitoring bone diseases.

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