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Abstract #2776

Quantitative MRI  Study of Diabetic Bone Marrow Microvascular Disease

Pianpian Chen1, Weiyin Vivian Liu2, and Yunfei Zha3
1Hospital of Stomatology Wuhan University, Wuhan, China, 2MR Research, GE Healthcare, Beijing, China, 3Renmin Hospital of Wuhan University, Wuhan, China

We quantitatively evaluate the microvascular permeability of lumbar marrow changes in alloxan-induced diabetic rabbits using dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) . And to investigate whether texture analysis based on permeability parameter Ktrans map of DCE-MRI can be used to assess the fine alterations of lumbar marrow structures in early-stage diabetic rabbits.

Our results confirm that texture analysis parameters based on DCE-MRI quantitative parameter Ktrans map are feasible to identify the early-stage fine changes of lumbar marrow structure in diabetic rabbits.

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