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Abstract #2803

Magic Angle Directional Imaging (MADI) standard deviation maps correlate with knee pathology in a spontaneous injury model.

Karyn Elizabeth Chappell1, Djordje Brujic2, Mihailo Ristic2, Donald McRobbie3, Wladyslaw Gedroyc4, Catherine Van Der Straeten5, and Richard Meeson6
1Medicine, Orthopaedic Surgery, Stanford University, Redwood City, CA, United States, 2Mechanical Engineering, Imperial College London, London, United Kingdom, 3University of Adelaide, Adelaide, Australia, 4Imperial College London, London, United Kingdom, 5Imperial College London/Ghent University, Ghent, Belgium, 6Royal Veterinary College, London, United Kingdom

A proof of concept study in a spontaneous ligament rupture dog model assessed if the magic angle effect disappears in unhealthy tissue. Ten dogs were scanned using the MADI technique. Standard deviation (SD) maps of signal intensity were computed and measured in an interactive display. Three subjects showed abnormally high SD; two at the ACL origin, one in the trochlear articular cartilage. Fibre orientation maps showed either disorganised or highly organised collagen fibres in these subjects. On dissection two subjects had partially torn ACLs and the other a fibrocartilage lesion. There was excellent correlation between the MADI and dissection findings.

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