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Abstract #2814

Dynamic multinuclear measurements in the calf with a dedicated RF coil while taking into account the nuclear Overhauser enhancement effect.

Alfredo Liubomir Lopez Kolkovsky1,2, Benjamin Marty1,2, Marc Lapert3, Eric Giacomini1, and Pierre G Carlier1,2
1NMR Laboratory, Institute of Myology, Paris, France, 2NMR Laboratory, CEA/DRF/IBFJ/MIRCen, Paris, France, 3Siemens Healthcare SAS, Saint-Denis, France

Interleaving multinuclear NMR measurements in the muscle during a transient state enriches the value of the exam by generating multiple data sets simultaneously. Here we show the results of our multinuclear interleaved approach using a 1H/31P dual-tune RF coil dedicated for calf experiments during an exercise and an ischemia-hyperemia paradigm. The nuclear Overhauser enhancement effect, which is dependent on the sequence and RF design, is characterized and its impact on rephosphorylation rate estimation and the [Pi]/[PCr] ratio is evaluated. The proposed methodology constitutes a powerful tool to evaluate mitochondrial function and metabolic efficiency in vivo.

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