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Abstract #2833

Evaluation of Knee Osteoarthritis (OA) Using 3D Ultrashort-Echo-Time Cones Magnetization Transfer (3D UTE-Cones-MT) Imaging

Xiaodong Zhang1,2, Ya-jun Ma2, Aria Ashir2, Mei Wu2, Zhao Wei2, Eric Y Chang3, and Jiang Du2
1The third affilated hospital of Southern Medical Univerisity, Guangzhou, China, 2Department of Radiology, University of California, San Diego, CA, United States, 3Radiology Service, VA San Diego Healthcare System, San Diego, CA, United States

Magnetization transfer (MT) imaging has been used for indirect assessment of macromolecules in biological tissues. In this study, we explore the value of the 3D UTE-Cones-MT sequence for volumetric quantification of magnetization transfer ratio (MTR) and macromolecular proton fraction(f) in menisci of healthy volunteers and patients with different degrees of OA. The primary results demonstrate that this method can detect compositional changes in meniscus and can be used to differentiate healthy subjects from patients with mild or advanced OA.

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