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Abstract #2836

Investigating relationship between creatine kinase kinetics and total NAD levels in human skeletal muscle in vivo using 31P MRS at 7.0T 

Deepa Thakuri1, Puneet Bagga1, Dushyant Kumar1, and Ravinder Reddy1
1Radiology, University of Pennsylvania, philadelphia, PA, United States

Nicotinamide adenine dinucleotide (NAD) plays an important role in cellular metabolism and it is important to study its correlation with other metabolites of the skeletal muscle. Phosphocreatine (PCr) present in abundant amount in the skeletal muscle facilitates the generation of ATP by conversion into creatine. 31P-MRS is a common technique used to study PCr recovery kinetics and its application has been shown in various diseases related to mitochondrial disorders. In this study, we aim to investigate the relationship between PCr recovery kinetics, total NAD concentration, and age.

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