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Abstract #2837

Assessment of skeletal muscle pathology in Dystrophin-deficient mice using structural and functional Diffusion MRI

Rina Ito1,2, Junichi Hata3,4, Mayu Iida1,2, Fumiko Seki2, Mitsuki Rikitake1,2, Yuji Komaki2, Chihoko Yamada2, Daisuke Nakashima4, Hirotaka James Okano3,4, and Takako Shirakawa1
1Department of Radiology, Faculty of Health Sciences, Tokyo Metropolitan University, Tokyo, Japan, 2Live Imaging Center, Central Institute for Experimental Animals, Kanagawa, Japan, 3Jikei University School of Medicine, Tokyo, Japan, 4Keio University School of Medicine, Tokyo, Japan

To analyze the disease of muscular dystrophy noninvasively, we assessed the degeneration of skeletal muscle and the distinction depending on types of muscle fibers, with changing parameters based on the sequence of diffusion weighted imaging. The mdx mice were used for longitudinal evaluation at the age from 5 to 10 weeks. We confirmed conventional diffusion tensor imaging could evaluate the pathological structure. Moreover, by applying the advanced imaging such as time-dependent diffusion MRI, we could demonstrate the functional characteristics of skeletal muscle cell and to detect micro-level condition of degeneration in mdx-mice.

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