To analyze the disease of muscular dystrophy noninvasively, we assessed the degeneration of skeletal muscle and the distinction depending on types of muscle fibers, with changing parameters based on the sequence of diffusion weighted imaging. The mdx mice were used for longitudinal evaluation at the age from 5 to 10 weeks. We confirmed conventional diffusion tensor imaging could evaluate the pathological structure. Moreover, by applying the advanced imaging such as time-dependent diffusion MRI, we could demonstrate the functional characteristics of skeletal muscle cell and to detect micro-level condition of degeneration in mdx-mice.
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