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Abstract #2840

Gadolinium deposition in cortical Bone after repeated administration of Magnevist and Gadovist assessed by ultrashort echotime based T1 mapping

Kaixuan Zhao1, Shisi Li2, Keyan Yu2, Jian Wang2, Xiaodong Zhang2, Qinqin Yu2, Cuiling Zhu2, Yingjie Mei3,4, Pu Xu3, Peiwei Yi3, Jiang Du5, and Yanqiu Feng3
1Southern Medical University, Guang Zhou, China, 2Imaging department of Southern Medical University affiliated the third hospital, Guang Zhou, China, 3School of Biomedical Engineering, Guangdong Provincial Key Laborary of Medical Image Processing, Southern Medical University, Guang Zhou, China, 4Philips Healthcare, Guang Zhou, China, 5Department of Radiology, University of California San Diego, San Diego, CA, United States

In this preclinical study, we assessed feasibility of evaluating Gadolinium deposition in cortical bone by using recently developed actual flip angle variable repetition time 3D ultrashort echotime technique in rabbit model at 7T. Twenty times of administration of clinical equivalent dose of Magnevist and Gadovist that normalized according to body surface by U.S. FDA recommendation, and three times the dose of Gadovist (high-dose group) were investigated. Significant lower T1 values were observed in Magnevist administration group, Gadovist administration group and high-dose Gadovist administration group compared to control group, suggested T1 mapping might be a potential biomarker for evaluating Gadolinium deposition.

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