Abstract #2840

Gadolinium deposition in cortical Bone after repeated administration of Magnevist and Gadovist assessed by ultrashort echotime based T1 mapping

Kaixuan Zhao¹, Shisi Li², Keyan Yu², Jian Wang², Xiaodong Zhang², Qinqin Yu², Cuiling Zhu², Yingjie Mei^3,4, Pu Xu³, Peiwei Yi³, Jiang Du⁵, and Yanqiu Feng³

¹Southern Medical University, Guang Zhou, China, ²Imaging department of Southern Medical University affiliated the third hospital, Guang Zhou, China, ³School of Biomedical Engineering, Guangdong Provincial Key Laborary of Medical Image Processing, Southern Medical University, Guang Zhou, China, ⁴Philips Healthcare, Guang Zhou, China, ⁵Department of Radiology, University of California San Diego, San Diego, CA, United States

In this preclinical study, we assessed feasibility of evaluating Gadolinium deposition in cortical bone by using recently developed actual flip angle variable repetition time 3D ultrashort echotime technique in rabbit model at 7T. Twenty times of administration of clinical equivalent dose of Magnevist and Gadovist that normalized according to body surface by U.S. FDA recommendation, and three times the dose of Gadovist (high-dose group) were investigated. Significant lower T1 values were observed in Magnevist administration group, Gadovist administration group and high-dose Gadovist administration group compared to control group, suggested T1 mapping might be a potential biomarker for evaluating Gadolinium deposition.

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