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Abstract #2839

23Na MRI of human intervertebral cervical discs in Mucopolysaccharidosis type II

Lenka Minarikova1, Alena Svatkova2, Wolfgang Bogner1, Siegfried Trattnig1,3, Thomas Stulnig2, and Stephan Gruber1
1High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 2Clinical Division for Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, Vienna, Austria, 3CD Laboratory for Clinical Molecular MR Imaging, Vienna, Austria

Spinal skeletal disease is one of least therapy responding symptoms in MPS patients. Cervical spine of three MPS II patients and three matched controls was measured using 23Na MRI at 7T. There was a significant difference in intervertebral discs of MPS II patient compared to controls. 23Na MRI represents a potential quantitative method for assessment of cervical disc degeneration in MPS II patients and could serve as a potential marker used in monitoring of emerging therapies.

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