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Abstract #2868

Using Simultaneous Multi-echo Fitting to Accelerate Magnetic Resonance Spectroscopic Relaxometry

Patrick J Bolan1, Gregory J Metzger1, Dinesh Deelchand1, and Malgorzata Marjanska1
1Radiology / Center for Magnetic Resonance Research, University of Minnesota-Twin Cities, Minneapolis, MN, United States

Measurements of metabolite T2 relaxation constants can be valuable biomarkers of aging and disease. The conventional method for measuring multiple metabolite T2s is to independently fit spectra from a multi-TE and then separately fit the amplitudes to an exponential decay to estimate T2. In this work we implement a simultaneous fitting approach to fit all of the multi-TE spectra at the same time by incorporating the transverse relaxation in the model. This approach greatly reduces the degrees of freedom and enable T2 estimation in noisy data, which may be used to shorten acquisition times and/or measure smaller regions.

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