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Abstract #2870

Assessment of partial volume effects in MRS voxels applying an Altas-based brain segmentation to high-resolution 3D MRI of rat brain

Chi-Hyeon Yoo1,2, Hyeon-Man Baek2, and Bo-Young Choe1
1The Catholic University of Korea, Seoul, Republic of Korea, 2Gacheon University, Incheon, Republic of Korea

The aim of this study was to apply the atlas-based brain segmentation to high-resolution 3D MRI of the mice brain, to assess a partial volume effect in the voxel. The altas-based segmentation successfully decomposed high-resolution 3D MRI into various anatomical compartments, and by volumetrically analyzing binary masks of the tissue compartment and voxels, a true contribution of the intended tissue compartment in the localized voxel can be assessed. By analyzing the metabolite-specific volume masks, an agreement of the localization between metabolites was evaluated. By evaluating the true contribution of the intended compartment and metabolite-specific agreement, localization reliability can be improved.

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