Abstract #2872

Optimized PRESS Echo Time for Quantifying Relative ω-3 Fat Content at 9.4T In Vivo

Clara J. Fallone¹, Anthony G. Tessier ^1,2, Catherine J. Field³, and Atiyah Yahya^1,2

¹Department of Oncology, University of Alberta, Edmonton, AB, Canada, ²Department of Medical Physics, Cross Cancer Institute, Edmonton, AB, Canada, ³Department of Agricultural, Food, and Nutritional Science, University of Alberta, Edmonton, AB, Canada

Omega-3 (ω-3) fat content in adipose tissue is relevant to the study of disease. It is challenging to quantify with Magnetic Resonance Spectroscopy (MRS) due to its low concentration in vivo. In addition, its resonance is difficult to resolve from that of the non-ω-3 protons, even at 9.4T. A PRESS (Point RESolved Spectroscopy) echo time of 109ms was determined to yield resolved ω-3 (≈ 0.98ppm) and non-ω-3 (≈ 0.9ppm) methyl peaks at 9.4T. The efficacy of the sequence was verified on oil phantoms and on rats fed a high ω-3 fat diet.

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