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Abstract #2890

T2 relaxation times of seven individual macromolecules in rat brain 1H MR Spectra at 9.4T: single inversion recovery and AMARES post processing  

Dunja Simicic1,2, Veronika Rackayova2, and Cristina Cudalbu2
1LIFMET, EPFL, Lausanne, Switzerland, 2CIBM, EPFL, Lausanne, Switzerland

At short echo times 1H-MR spectra contain the contribution of mobile macromolecules (MM), i.e. broader resonances characterized by shorter relaxation times (T1,T2) which underlie the narrower peaks of metabolites. There are very few studies assessing MM T2 relaxation times, with only one study reporting T2-s of individual MM peaks in the full ppm range at 9.4T in the human brain. In this work we present a new approach: single inversion recovery with an optimized inversion time combined with AMARES post-processing. Using this technique we quantified 10-MM components and estimated T2 relaxation times (for 7-MM components) in rat brain at 9.4T.

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