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Abstract #2889

Singlet state encoded magnetic resonance (SISTEM) spectroscopy

Andrey Pravdivtsev1, Frank D. Sönnichsen2, and Jan-Bernd Hövener1
1Medical faculty, MOIN CC, Kiel University, Kiel, Germany, 2Otto Diels Institute for Organic Chemistry, Kiel University, Kiel, Germany

MRS provides a non-invasive window into an in vivo biochemistry – basically a virtual biopsy. Here, we present two novel MRS sequences (SISTEM-1 and 2) and method to selectively prepare and detect the signal of endogenous metabolites. The long-lived signal of NAA-CH2 protons was isolated by the strong suppression of H2O and lipid signals using broad-band saturation or double-quantum filter. The frequency of the modulated NAA-CH2 signal was measured and associated with a pH value. Non-invasive measurement of pH value, imaging of drug distribution are only some of the possible applications.

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