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Abstract #2895

Effect of water suppression and metabolite cycling on quantification of 1H MRS spectra in the human brain at 3 Tesla

Dinesh K Deelchand1 and Pierre-Gilles Henry1
1Center for Magnetic Resonance Research, Radiology, University of Minnesota, Minneapolis, MN, United States

This study investigates the effect of water suppression and metabolite cycling on metabolite quantification and macromolecules in 1H MRS. Single-voxel semi-LASER spectra and metabolite-nulled spectra (macromolecules) were acquired in the posterior cingulate cortex in the human brain at 3T using three different schemes: VAPOR, metabolite-cycling (MC), and metabolite-cycling combined with a single water suppression pulse. Results show that macromolecule signal and several metabolites (ascorbate, total creatine, glutamate, and glutathione) have higher in concentration when using MC compared to VAPOR. Combining MC with a single water suppression pulse results in concentrations in between those obtained with VAPOR and MC.

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