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Abstract #2900

Improved GABA editing and macromolecule suppression with adiabatic and highly selective Gaussian pulses at 7T

Song-I Lim1 and Lijing Xin1
1Centre d'Imagerie BioMédicale (CIBM), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

The aim of the study is to improve the efficiency of GABA editing and macromolecule suppression at 7T. An asymmetric adiabatic pulse with broad inversion bandwidth was applied at 1.9 ppm to invert 1.5 – 1.9 ppm range and a narrow Gaussian pulse with 95 Hz of bandwidth (0.95 < Mz) was applied at 1.7 ppm to suppress macromolecule. In the GABA and lysine phantom tests, this scheme shows ± 9 Hz of signal loss threshold in comparison with highly selective inversion pulse without macromolecule suppression (± 6 Hz of threshold) and symmetric pulses (± 3 Hz of threshold).

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