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Abstract #2899

A method to estimate GABA free from homocarnosine and macromolecular overlap through a combination of STEAM and J-difference editing sLASER at 7T

Karl Landheer1, Hetty Prinsen2, Ognen A Petroff3, Douglas L Rothman2, and Christoph Juchem1,4
1Biomedical Engineering, Columbia University, New York, NY, United States, 2Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States, 3Neurology, Yale University, New Haven, CT, United States, 4Radiology, Columbia University, New York, NY, United States

The aim of this work was to develop a novel method to assess accurately both the relative concentrations of homocarnosine as well as GABA free from overlapping creatine, homocarnosine and macromolecule signal. This was achieved via the combination of short echo time STEAM and MEGA-sLASER experiments at 7T. The metabolites GABA and homocarnosine were measured in 6 healthy control subjects, and in a single subject medicated with isoniazid. It was found that (16.6 ± 10.2)% of the supposed GABA signal originated from homocarnosine, and that isoniazid caused a significantly elevated concentration of GABA and homocarnosine in a single subject.

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