Downfield MRS provides a great tool to detect and quantify metabolites downfield to water including NAD and ATP. Acquisition of downfield MR spectrum in vivo without water suppression leads to the possibility of detection of many cross-relaxing/exchanging resonances. The T2 of many species occurring downfield of water are relatively short which require short echo time MRS methods. EBURP pulses have been shown to reliably excite narrow spectral region with minimum phase response. In this study, we generated new pulse sequences for single voxel and 3D spectral selective EBURP excitation to detect cerebral NAD from human brain at 7T.
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