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Abstract #2917

Diffusion MR spectroscopy at 7T with no water suppression is sensitive to measuring diffusion properties of metabolites in the corpus callosum

Yasmin Mzayek1,2, Francesca Branzoli3, Thomas Troalen4, Yann Le Fur1,2, Patrick Viout1,2, Tangi Roussel1,2, Stanislas Rapacchi1,2, Maxime Guye1,2, Itamar Ronen5, Wafaa ZAARAOUI1,2, and Jean-Philippe RANJEVA1,2
1Aix-Marseille Université, CNRS, CRMBM, Marseille, France, 2APHM, Hôpital de la Timone, Pôle d’Imagerie Médicale, CEMEREM, Marseille, France, 3Brain and Spine Institute - ICM, Centre for NeuroImaging Research - CENIR, Paris, France, 4Siemens Healthineers SAS, Saint-Denis, France, 5Department of Radiology Leiden University Medical Center, Leiden, Netherlands

We implemented a diffusion-weighted semi-LASER single voxel spectroscopy sequence with no water suppression to measure mean diffusivity and fractional anisotropy within two volumes-of-interest in the corpus callosum. Without water suppression, we were able to decrease acquisition time and use the water signal for phase, frequency, and eddy current corrections. We measured the signal decay of N-acetylaspartate (tNAA), creatine (tCr), choline (tCho), and water to derive diffusion outcomes and compare between the two volumes-of-interest. Our implementation was done in feasible time for in vivo measurements. Further development can lead to more specific assessments of brain microstructure and pathophysiology.

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