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Abstract #2923

Detection of acetyl-carnitine in the human heart in vivo using long echo-time 1H-MRS at 3T 

Joe Pollacco1,2, William Clarke3, Aaron Hess1, Dragana Savic1,4, Christopher T Rodgers1,5, Damian Tyler1,4, Jack JJ Miller1,2,4, and Ladislav Valkovic1,6
1Oxford Centre for Clinical Magnetic Resonance Research, RDM Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom, 2Department of Physics, University of Oxford, Oxford, United Kingdom, 3Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United Kingdom, 4Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom, 5Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom, 6Department of Imaging Methods, Slovak Academy of Sciences, Bratislava, Slovakia

Cardiac acetyl-carnitine plays an important role in fat metabolism. Decreased carnitine concentration has been reported in heart failure, but it has previously been difficult to measure acetyl-carnitine in-vivo. We show for the first time that it is possible to detect a clear acetyl-carnitine resonance at δ=2.1ppm without lipid contamination within the heart using a long echo time semi-LASER sequence at 3T. This validates the finding in skeletal muscle that the T2 of acetyl-carnitine is much longer than its surrounding lipid signals. Further work is underway to investigate variability of the acetyl-carnitine signal postprandially.

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