A proof-of-concept generalized linear model to characterize the relationships between brain metabolite concentrations and pain perception is presented, explicitly accounting for differences in regional grey matter (GM) density. Brain metabolite concentrations measured with magnetic resonance spectroscopy (MRS), and pain perception characterized using quantitative sensory testing (QST), were significantly associated in a cohort of patients with chronic pain. These results contribute to the expanding literature that supports the utility of neuroimaging to understand the underlying mechanisms of centralized chronic pain.
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