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Abstract #2924

Association of brain metabolite concentrations and pain perception in a cohort of patients with chronic pain

Maame Owusu-Ansah1, Candace C. Fleischer1, and Daniel E. Harper2
1Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States, 2Department of Anesthesiology, Emory University School of Medicine, Atlanta, GA, United States

A proof-of-concept generalized linear model to characterize the relationships between brain metabolite concentrations and pain perception is presented, explicitly accounting for differences in regional grey matter (GM) density. Brain metabolite concentrations measured with magnetic resonance spectroscopy (MRS), and pain perception characterized using quantitative sensory testing (QST), were significantly associated in a cohort of patients with chronic pain. These results contribute to the expanding literature that supports the utility of neuroimaging to understand the underlying mechanisms of centralized chronic pain.

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