Accurate detection of hepatocellular lipid content (HLC) in individuals with alcohol use disorder (AUD) is needed for early diagnosis of hepatic steatosis, a harbinger of serious liver diseases such as cirrhosis. Using a standard clinical 3T system and ultrashort-TE liver MRS, the proposed sequence employed asymmetric RF pulses with spoiler gradient cycling to achieve minimal TE of 5ms and minimal T2 errors for reliable signal quantification. No difference was found in HCL and choline levels between controls and AUD subjects. After a 3-week abstinence period, changes in hepatic fat and choline levels were observed in subjects with AUD.
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