Abstract #2926

A 9-month follow-up study in patients with delayed neurologic sequelae after CO intoxication using absolute quantification of 1H MRS and DKI

Yi-Chen Tsai¹, Hui-Ru Tsai¹, Ming-Chung Chou², Ping-Hong Lai^3,4, Jie-Yuan Li^5,6, and Cheng-Wen Ko¹

¹Dept. of Computer Science and Engineering, National Sun Yat-sen University, Kaohsiung, Taiwan, ²Dept. of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan, ³Dept. of Radiology, Veterans General Hospital-Kaohsiung, Kaohsiung, Taiwan, ⁴School of Medicine, National Yang-Ming University, Taipei, Taiwan, ⁵Dept. of Neurology, E-Da Hospital, Kaohsiung, Kaohsiung, Taiwan, ⁶School of Medicine, I-Shou University, Kaohsiung, Kaohsiung, Taiwan

In this study, we explored the metabolic changes in WM of patients with and without DNS using 1H MRS and DKI longitudinally at 1 week and 1, 3, and 9 months after CO intoxication. Increased Cr and Cho were observed at early stage in WM of patients with DNS. Decreased tNAA showed higher correlation with the presence of WM lesion than of DNS. The chronic change of Ins and Glx in patients with DNS implies themselves as potential indices to provide valuable information for monitoring DNS development.

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