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Abstract #2930

Effect of DNA methylation levels of dopamine D4 receptor gene on GABA concentrations in the mPFC in children with primary nocturnal enuresis

Zijun Li1, Xiaoyang Li1, and Bing Yu1
1Shengjing Hospital of China Medical University, Shenyang, China

In the current study we investigated the effect of DRD4 DNA methylation levels on the GABA concentrations in mPFC in PNE children.

Our results suggested the DNA methylation level of DRD4 is associated with increased GABA concentrations in the mPFC in PNE children. The effects of epigenetic variation of the DRD4 DNA on GABA concentrations in mPFC may help us understand the epigenetic susceptibility of the DRD4 DNA methylation to PNE.

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