Abstract #2931

Metabolic Profile Differences in Serum of Sepsis Patients may Identify Survivors and Non-Survivors

Virendra Kumar¹, Naveen Kumar MS², sujeet kumar mewar¹, Pradeep Kumar¹, Naveet Wig², Prayas Sethi², and Sanjeev Sinha²

¹Department of NMR, All India Institute of Medical Sciences, New Delhi, India, ²Department of Medicine, All India Institute of Medical Sciences, New Delhi, India

The present study reported the differences in metabolic profile of serum samples from patient with sepsis to identify survivor and non-survivor (day 0) using NMR metabolomics. A significantly higher concentration of tyrosine, histidine, methionine, betaine, creatine, phosphocreatine and choline in the serum of sepsis patients who did not survive septic shock compared to survivors. These findings suggest that metabolic alterations at day 0 may predict the survival of the septic patients.

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